Antimicrobial Resistance (AMR) Research Group

Diversity, transmission and selective pressure on the proteome of Pseudomonas aeruginosa

Shah, A., Shah, H., Duncan, L. and Ward, M. 2023. Diversity, transmission and selective pressure on the proteome of Pseudomonas aeruginosa. in: Shah, H., Gharbia, S., Shah, A., Tranfield, E. and Clive, T. (ed.) Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry Industrial and Environmental Applications Wiley. pp. 183-201

Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms

Parmar, A., Lakshminarayanan, R., Iyer, A., Goh, E.T.L., To, T.Y., Yam, J.K.H., Yang, L., Newire, E., Robertson, M.C., Prior, S.H., Breukink, E., Madder, M. and Singh, I. 2023. Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms. European Journal of Medicinal Chemistry. 261.  https://doi.org/10.1016/j.ejmech.2023.115853

Application of MALDI-TOF MS in bioremediation and environmental research

Russo, C. and Purchase, D. 2023. Application of MALDI-TOF MS in bioremediation and environmental research. in: Shah, H.N., Gharbia, S.E., Shah, A., Tranfield, E.Y. and Thompson, K.C. (ed.) Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry: Industrial and Environmental Applications Wiley. pp. 255-282

Microbiological identification using MALDI-TOF and tandem mass spectrometry: industrial and environmental applications 

Shah, H.N., Gharbia, S.E., Shah, A., Tranfield, E.Y. and Thompson, K.C. (ed.) 2023. Microbiological identification using MALDI-TOF and tandem mass spectrometry: industrial and environmental applications. Wiley. 

Progress in the microbiological applications of mass spectrometry: From electron impact to soft ionization techniques, MALDI-TOF MS and beyond 

Raptakis, E, Shah, A., Gharbia, S.E., Shah, L.M.N, Francese, S., Tranfield, E.Y., Duncan, L. and Shah, H.N. 2023. Progress in the microbiological applications of mass spectrometry: From electron impact to soft ionization techniques, MALDI-TOF MS and beyond. in: Shah, H.N., Gharbia, S.E., Shah, A., Tranfield, E.Y. and Thompson, K.C. (ed.) Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry: Industrial and Environmental Applications Wiley. pp. 1-44 

Regulatory and innovative mechanisms of bacterial quorum sensing-mediated pathogenicity: a review 

Tripathi, S., Purchase, D., Govarthanan, M., Chandra, R. and Yadav, S. 2023. Regulatory and innovative mechanisms of bacterial quorum sensing-mediated pathogenicity: a review. Environmental Monitoring and Assessment. 195 (1). https://doi.org/10.1007/s10661-022-10564-0 

New teixobactin analogues with a total lactam ring 

Scioli, G., Marinaccio, L., Bauer, M., Kamysz, W., Parmar, A., Newire, E., Singh, I., Stefanucci, A. and Mollica, A. 2023. New teixobactin analogues with a total lactam ring. ACS Medicinal Chemistry Letters. 14 (12), pp. 1603-1892. https://doi.org/10.1021/acsmedchemlett.3c00435  

Phylogenomic and comparative genomic studies robustly demarcate two distinct clades of Pseudomonas aeruginosa strains: proposal to transfer the strains from an outlier clade to a novel species Pseudomonas paraeruginosa sp. nov 

Rudra, B., Duncan, L., Shah, A., Shah, H. and Gupta, R. 2022. Phylogenomic and comparative genomic studies robustly demarcate two distinct clades of Pseudomonas aeruginosa strains: proposal to transfer the strains from an outlier clade to a novel species Pseudomonas paraeruginosa sp. nov. International Journal of Systematic and Evolutionary Microbiology. 72 (11), pp. 1-15. https://doi.org/10.1099/ijsem.0.005542  

The bacterial urban resistome: recent advances 

Vassallo, A., Kett, S., Purchase, D. and Marvasi, M. 2022. The bacterial urban resistome: recent advances. Antibiotics. 11 (4), pp. 1-17. https://doi.org/10.3390/antibiotics11040512 

Educational activities for students and citizens supporting the One-Health approach on antimicrobial resistance 

Marvasi, M., Casillas, L., Vassallo, A. and Purchase, D. 2021. Educational activities for students and citizens supporting the One-Health approach on antimicrobial resistance. Antibiotics. 10 (12). https://doi.org/10.3390/antibiotics10121519 

Antibiotic-resistant genes and bacteria as evolving contaminants of emerging concerns (e-CEC): is it time to include evolution in risk assessment? 

Vassallo, A., Kett, S., Purchase, D. and Marvasi, M. 2021. Antibiotic-resistant genes and bacteria as evolving contaminants of emerging concerns (e-CEC): is it time to include evolution in risk assessment? Antibiotics. 10 (9), pp. 1-11. https://doi.org/10.3390/antibiotics10091066 

Antibacterial apple cider vinegar eradicates methicillin resistant Staphylococcus aureus and resistant Escherichia coli 

Yagnik, D., Ward, M. and Shah, A. 2021. Antibacterial apple cider vinegar eradicates methicillin resistant Staphylococcus aureus and resistant Escherichia coli. Scientific Reports. 11 (1), pp. 1-7. https://doi.org/10.1038/s41598-020-78407-x  

Identification of a Type IV-A CRISPR-Cas system located exclusively on IncHI1B/IncFIB plasmids in Enterobacteriaceae 

Newire, E., Aydin, A., Juma, S., Enne, V. and Roberts, A. 2020. Identification of a Type IV-A CRISPR-Cas system located exclusively on IncHI1B/IncFIB plasmids in Enterobacteriaceae. Frontiers in Microbiology. 11. https://doi.org/10.3389/fmicb.2020.01937  

Isolation of an antimicrobial-resistant, biofilm-forming, Klebsiella grimontii isolate from a reusable water bottle 

Hubbard, A.T.M., Newire, E., Botelho, J., Reiné, J., Wright, E., Murphy, E.A., Hutton, W. and Roberts, A.P. 2020. Isolation of an antimicrobial-resistant, biofilm-forming, Klebsiella grimontii isolate from a reusable water bottle. MicrobiologyOpen. 9 (6), pp. 1128-1134. https://doi.org/10.1002/mbo3.1023  

Mobile colistin resistance gene mcr-1 detected on an IncI1 plasmid in Escherichia coli from meat 

Brouwer, M.S.M., Goodman, R.N., Kant, A., Newire, E., Roberts, A.P. and Veldman, K.T. 2020. Mobile colistin resistance gene mcr-1 detected on an IncI1 plasmid in Escherichia coli from meat. Journal of Global Antimicrobial Resistance. 23, pp. 145-148. https://doi.org/10.1016/j.jgar.2020.08.018  

MALDI TOF MS and currently related proteomic technologies in reconciling bacterial systematics 

Shah, H., Shah, A., Belgacem, O., Ward, M., Dekio, I., Selami, L., Duncan, L., Bruce, K., Xu, Z., Mkrtchyan, H., Cave, R., Shah, L. and Gharbia, S. 2020. MALDI TOF MS and currently related proteomic technologies in reconciling bacterial systematics. in: Bridge, P., Smith, D. and Stackebrandt, E. (ed.) Trends in the Systematics of Bacteria and Fungi Wallingford, UK CAB International. pp. 93-118 

Detection of extended-spectrum β-lactamase and carbapenemase activity in Gram-negative bacilli using liquid chromatography - tandem mass spectrometry 

Serafim, V., Shah, A., Licker, M., Horhat, F., Vulpie, S., Musuroi, C. and Muntean, D. 2020. Detection of extended-spectrum β-lactamase and carbapenemase activity in Gram-negative bacilli using liquid chromatography - tandem mass spectrometry. Infection and Drug Resistance. 13, pp. 4021-4029. https://doi.org/10.2147/IDR.S267160  

Antibiotic selective pressure in microcosms: pollution influences the persistence of multidrug resistant Shigella flexneri 2a YSH6000 strain in polluted river water samples 

Maruzani, R., Pathak, A., Ward, M., Serafim, V., Pantoja Munoz, L., Shah, A. and Marvasi, M. 2020. Antibiotic selective pressure in microcosms: pollution influences the persistence of multidrug resistant Shigella flexneri 2a YSH6000 strain in polluted river water samples. Environmental Technology and Innovation. 19. https://doi.org/10.1016/j.eti.2020.100821  

Effect of Berberine on in vitro metabolism of Sulfonylureas: a herb-drug interactions study 

Singh, A., Zhao, K., Bell, C. and Shah, A. 2020. Effect of Berberine on in vitro metabolism of Sulfonylureas: a herb-drug interactions study. Rapid Communications in Mass Spectrometry. 34 (S4), pp. 1-12. https://doi.org/10.1002/rcm.8651  

SRL pathogenicity island contributes to the metabolism of D-aspartate via an aspartate racemase in Shigella flexneri YSH6000 

Henríquez, T., Salazar, J., Marvasi, M., Shah, A., Corsini, G. and Toro, C. 2020. SRL pathogenicity island contributes to the metabolism of D-aspartate via an aspartate racemase in Shigella flexneri YSH6000. PLoS ONE. 15 (1), pp. 1-14. https://doi.org/10.1371/journal.pone.0228178  

Comparative proteomic profiling of methicillin-susceptible and resistant Staphylococcus aureus 

Xu, Z., Chen, J., Vougas, K., Shah, A., Shah, H., Misra, R. and Mkrtchyan, H. 2020. Comparative proteomic profiling of methicillin-susceptible and resistant Staphylococcus aureus. Proteomics. 20 (2), pp. 1-6. https://doi.org/10.1002/pmic.201900221  

A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants 

Marano, R., Fernandes, T., Manaia, C., Nunes, O., Morrison, D., Berendonk, T., Kreuzinger, N., Telson, T., Corno, G., Fatta-Kassinos, D., Merlin, C., Topp, E., Jurkevitch, E., Henn, L., Scott, A., Heß, S., Slipko, K., Laht, M., Kisand, V., Di Cesare, A., Karaolia, P., Michael, S., Petre, A., Rosal, R., Pruden, A., Riquelme, V., Agüera, A., Esteban, B., Luczkiewicz, A., Kalinowska, A., Leonard, A., Gaze, W., Adegoke, A., Stenstrom, T., Pollice, A., Salerno, C., Schwermer, C., Krzeminski, P., Guilloteau, H., Donner, E., Drigo, B., Libralato, G., Guida, M., Bürgmann, H., Beck, K., Garelick, H., Tacão, M., Henriques, I., Martínez-Alcalá, I., Guillén-Navarro, J., Popowska, M., Piotrowska, M., Quintela-Baluja, M., Bunce, J., Polo-López, M., Nahim-Granados, S., Pons, M., Milakovic, M., Udikovic-Kolic, N., Ory, J., Ousmane, T., Caballero, P., Oliver, A., Rodriguez-Mozaz, S., Balcazar, J., Jäger, T., Schwartz, T., Yang, Y., Zou, S., Lee, Y., Yoon, Y., Herzog, B., Mayrhofer, H., Prakash, O., Nimonkar, Y., Heath, E., Baraniak, A., Abreu-Silva, J., Choudhury, M., Pantoja Munoz, L., Krizanovic, S., Brunetti, G., Maile-Moskowitz, A., Brown, C. and Cytryn, E. 2020. A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants. Environment International. 144, pp. 1-11. https://doi.org/10.1016/j.envint.2020.106035